Q1: What are the grades of WestPoint Pharmaceutical's Microcrystalline Cellulose (MCC) and their specific applications?

Westpoint Pharmaceutical’s DESU^® Microcrystalline Cellulose (MCC) is categorized into three main series. Below is a breakdown of each grade and its optimal application scenarios for oral solid dosage formulations:

1. PH Series (Standard Pharm Grade MCC)

• DESU^® MCC PH-101: A fine powder grade featuring small particle size, high specific surface area, and excellent compressibility. It is highly versatile, suitable for wet granulation, dry granulation, and direct compression. Ideal for formulations like Levofloxacin Tablets, Atorvastatin Calcium Tablets, and Apixaban Tablets—especially those with high API content requiring stringent moldability.
•  DESU^® MCC PH-102: The industry-standard workhorse. It offers a balanced profile of flowability and compressibility, making it the mainstream choice for direct tablet compression. Widely used in Amlodipine Besylate Tablets, it provides a wide processing window where hardness fluctuations have minimal impact on dissolution rates.
•  DESU^® MCC PH-112: An ultra-low moisture grade with Loss on Drying (LoD) of only 0.3%–0.6%. It exhibits controlled moisture uptake even at 25℃/75% RH. Specifically designed for moisture-sensitive APIs such as Vildagliptin and Clopidogrel Bisulfate, compatible with direct compression and dry granulation.
•  DESU^® MCC PH-200: A large-particle grade offering superior flowability and stable bulk density. Optimized for high-speed tablet pressing, ensuring consistent tablet weight variation and hardness for formulations like Rosuvastatin Calcium Tablets.
•  DESU^® MCC PH-301 / DESU^® MCC PH-302: High-density grades with bulk density increased by 36%–43% compared to standard MCC. They provide exceptional flow and filling properties, solving formulation challenges for high-dose drugs (API >60%). DESU^® MCC PH-301 is suited for small tablet diameters requiring high density, while DESU^® MCC PH-302 is optimized for high-speed direct compression (e.g., Acarbose Tablets, Dapagliflozin Tablets).

2. High-Performance MCC

•  DESU^® MCC 802: Engineered with an optimal fiber aspect ratio, it achieves robust compaction at low compression forces (>5kN) and ensures rapid disintegration. It is specifically developed for Orally Disintegrating Tablets (ODT) and sensitive materials like enzymes, antibiotics, and coated granules.
•  DESU^® MCC 1000: Features an enhanced fiber aspect ratio and a high water absorption rate (up to 410%). It requires very low compression force (<4kN) for effective tableting and effectively inhibits liquid exudation. Perfect for the solidification of liquid-active pharmaceutical ingredients (APIs) such as Vitamin D and volatile oils.

3. Super-Flow MCC

• DESU^® MCC 702: Combines superior flow with high compressibility (Carr Index <30%, Angle of Repose <39°). Designed for ultra-high-speed production (>40,000 tablets/hour), it maintains a tablet weight RSD of <1% and friability of <0.2%, while ensuring stable disintegration even at high hardness levels.

All DESU^® MCC grades are produced via WestPoint Pharmaceutical’s proprietary spray-drying technology. This process allows for precise control over microstructure and physicochemical properties, ensuring performance parity with leading international brands. It provides a reliable raw material solution for the industrial-scale manufacturing of oral solid dosage forms.