DISPE® L-HPC

Product Introduction

DISPE^® L-HPC is a high-performance, non-ionic cellulose ether specifically engineered for solid oral dosage formulations. With its unique fibrous morphology and high porosity, it rapidly absorbs water and swells, ensuring swift tablet disintegration and promoting the dissolution of active pharmaceutical ingredients (APIs). Beyond its primary role as a superdisintegrant, DISPE^® L-HPC also acts as an effective dry binder, significantly improving tablet hardness through mechanical interlocking without compromising disintegration. It is free from peroxides and exhibits excellent compatibility with a wide range of APIs, making it a stable and reliable choice for diverse pharmaceutical manufacturing processes.

Product Feature

• Rapid and Reliable Disintegration
• Dual-Function as Disintegrant and Dry Binder
• Enhanced Tablet Hardness
• Anti-Capping Performance
• Non-Ionic and Peroxide-Free for Superior Stability
• pH-Independent Swelling Behavior
• High Compatibility with APIs
• Optimized Particle Size for Critical Applications

Product Application

DISPE^® L-HPC is a versatile excipient widely applied in the production of oral solid dosage forms, demonstrating exceptional performance across multiple manufacturing techniques. It is a primary choice for direct compression processes, where it functions simultaneously as a dry binder and disintegrant at levels of 10–15%, and is equally effective in wet granulation—whether incorporated intragranularly to improve disintegration or extragranularly to enhance dissolution. For dry granulation via roller compaction, DISPE^® L-HPC improves ribbon stability and granule yield while maintaining rapid disintegration. It is also the ideal disintegrant for orally disintegrating tablets (ODTs), enabling disintegration within seconds, and serves as a crucial processing aid in extrusion-spheronization for pellet production as well as a dispersion and glidant agent in capsule filling to ensure uniform drug distribution and swift release. Typical usage rates range from 2% to 8% for disintegration purposes, and 10% to 15% in direct compression formulations.

Product Specification

Packaging

• 20-foot container can hold 10 to 11 metric tons of DISPE® L-HPC.
• Standard packaging of 20/25 kg per bag.